Randomization (2)0 if no randomization performed or not mentioned, 1 if partial or inadequate, 2 if adequate |

Placebo (2)0 if no placebo, 1 if inert placebo, 2 if compared to gold standard. |

Blinding (2)0 No blinding, 1 Single blinded, 2 Double blinded |

Objective measurement (1)Example: 1 if Colorimeter is used for melasma and 0 if MASI is used. |

Sample size more than 21 (1)Effect size of 0.5, alpha 0.05 and power 80 |

Sample selection and allocation concealment (1)0 if study is done on clinic staff or if person knows allocated group. 1 if appropriate. |

Economical (1)1 if intervention cheaper than gold standard |

Conflict of interest (1)0 if present, 1 if absent |

Withdrawal / Dropouts (1)0 if more than 1 in 5 (20%) or not mentioned, 1 if not |

Coherent endpoints & assessment times (1)0 if not mentioned or inappropriate, 1 if appropriate |

Co-Interventions (1)0 if multiple active ingredients tested, 1 if single |

Acceptable theory (1)0 if no rational theoretical basis, 1 if sound |

If a criteria is not mentioned in the publication, the criteria is not scored and gets 0 |

Powered by WordPress | SkinAid Copyright 2018