A Randomized, Evaluator-Blinded, Split-Face Comparison Study of the Efficacy and Safety of a Novel Mannitol Containing Monophasic Hyaluronic Acid Dermal Filler for the Treatment of Moderate to Severe Nasolabial Folds.

Criteria (Maximum score)	Score
Randomization	2/2
Placebo	1/2
Blinding	1/2
Objective measurement	1/1
Sample size more than 21	0/1
Sample selection and allocation concealment	1/1
Economical	0/1
Conflict of interest	1/1
Withdrawal / Dropouts	1/1
	1/1
Co-Interventions	0/1
Acceptable theory	1/1
Total	10/15

Interpretation is as follows:
13-15	Excellent study with substantial evidence
10-12	Good study. Evidence sufficient for practice
7-9	Average Study. Use the evidence with caution
4-6	Weak Study. Evidence not suitable for practice
0-3	Just an anecdotal claim